GaMF1
Modify Date: 2024-09-17 17:19:03
GaMF1 structure
|
Common Name | GaMF1 | ||
|---|---|---|---|---|
| CAS Number | 923689-76-3 | Molecular Weight | 426.318 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H20BrN5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GaMF1GaMF1 is a novel antimycobacterial compound that targets the F1FO-ATP synthase γ subunit loop;GaMF1 is bactericidal and is active against multidrug- as well as bedaquiline-resistant strains.Combining GaMF1 with bedaquiline or novel diarylquinoline analogues showed potentiation without inducing genotoxicity or phenotypic changes in a human embryonic stem cell reporter assay.GaMF1 presents an attractive lead for the discovery of a novel class of anti-tuberculosis F-ATP synthase inhibitors. |
| Name | GaMF1 |
|---|
| Description | GaMF1 is a novel antimycobacterial compound that targets the F1FO-ATP synthase γ subunit loop;GaMF1 is bactericidal and is active against multidrug- as well as bedaquiline-resistant strains.Combining GaMF1 with bedaquiline or novel diarylquinoline analogues showed potentiation without inducing genotoxicity or phenotypic changes in a human embryonic stem cell reporter assay.GaMF1 presents an attractive lead for the discovery of a novel class of anti-tuberculosis F-ATP synthase inhibitors. |
|---|---|
| References | 1. Adam Hotra, et al. Angew Chem Int Ed Engl. 2020 Aug 3;59(32):13295-13304. |
| Molecular Formula | C20H20BrN5O |
|---|---|
| Molecular Weight | 426.318 |
| InChIKey | PPJLELNIBHTXED-UHFFFAOYSA-N |
| SMILES | CCNc1cc(C)nc(Nc2ccc(NC(=O)c3cccc(Br)c3)cc2)n1 |