923689-76-3
923689-76-3 structure
- Name: GaMF1
- Chemical Name: GaMF1
- CAS Number: 923689-76-3
- Molecular Formula: C20H20BrN5O
- Molecular Weight: 426.318
- Create Date: 2022-07-06 18:11:32
- Modify Date: 2024-09-17 17:19:03
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GaMF1 is a novel antimycobacterial compound that targets the F1FO-ATP synthase γ subunit loop;GaMF1 is bactericidal and is active against multidrug- as well as bedaquiline-resistant strains.Combining GaMF1 with bedaquiline or novel diarylquinoline analogues showed potentiation without inducing genotoxicity or phenotypic changes in a human embryonic stem cell reporter assay.GaMF1 presents an attractive lead for the discovery of a novel class of anti-tuberculosis F-ATP synthase inhibitors.
| Name | GaMF1 |
|---|
| Description | GaMF1 is a novel antimycobacterial compound that targets the F1FO-ATP synthase γ subunit loop;GaMF1 is bactericidal and is active against multidrug- as well as bedaquiline-resistant strains.Combining GaMF1 with bedaquiline or novel diarylquinoline analogues showed potentiation without inducing genotoxicity or phenotypic changes in a human embryonic stem cell reporter assay.GaMF1 presents an attractive lead for the discovery of a novel class of anti-tuberculosis F-ATP synthase inhibitors. |
|---|---|
| References | 1. Adam Hotra, et al. Angew Chem Int Ed Engl. 2020 Aug 3;59(32):13295-13304. |
| Molecular Formula | C20H20BrN5O |
|---|---|
| Molecular Weight | 426.318 |