GaMF1
Names
[ CAS No. ]:
923689-76-3
[ Name ]:
GaMF1
Biological Activity
[Description]:
GaMF1 is a novel antimycobacterial compound that targets the F1FO-ATP synthase γ subunit loop;GaMF1 is bactericidal and is active against multidrug- as well as bedaquiline-resistant strains.Combining GaMF1 with bedaquiline or novel diarylquinoline analogues showed potentiation without inducing genotoxicity or phenotypic changes in a human embryonic stem cell reporter assay.GaMF1 presents an attractive lead for the discovery of a novel class of anti-tuberculosis F-ATP synthase inhibitors.
[References]
1. Adam Hotra, et al. Angew Chem Int Ed Engl. 2020 Aug 3;59(32):13295-13304.
Chemical & Physical Properties
[ Molecular Formula ]:
C20H20BrN5O
[ Molecular Weight ]:
426.318
Related Compounds
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