P53R3
Modify Date: 2024-09-25 10:15:41
P53R3 structure
|
Common Name | P53R3 | ||
|---|---|---|---|---|
| CAS Number | 922150-12-7 | Molecular Weight | 592.565 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H35Cl2N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of P53R3P53R3 is a novel p53 reactivator that restores sequence-specific DNA binding of the endogenously expressed p53(R175H) and p53(R273H) mutants in gel-shift assays; induces p53-dependent antiproliferative effects with much higher specificity and over a wider range of concentrations than PRIMA-1; strongly enhances the mRNA, total protein and cell surface expression of DR5. |
| Name | P53R3 |
|---|
| Description | P53R3 is a novel p53 reactivator that restores sequence-specific DNA binding of the endogenously expressed p53(R175H) and p53(R273H) mutants in gel-shift assays; induces p53-dependent antiproliferative effects with much higher specificity and over a wider range of concentrations than PRIMA-1; strongly enhances the mRNA, total protein and cell surface expression of DR5. |
|---|---|
| References | References 1. Weinmann L, et al. Cell Death Differ. 2008 Apr;15(4):718-29. View Related Products by Target MDM2-p53 |
| Molecular Formula | C32H35Cl2N5O2 |
|---|---|
| Molecular Weight | 592.565 |