P53R3

Names

[ Name ]:
P53R3

Biological Activity

[Description]:

P53R3 is a novel p53 reactivator that restores sequence-specific DNA binding of the endogenously expressed p53(R175H) and p53(R273H) mutants in gel-shift assays; induces p53-dependent antiproliferative effects with much higher specificity and over a wider range of concentrations than PRIMA-1; strongly enhances the mRNA, total protein and cell surface expression of DR5.

[References]

References 1. Weinmann L, et al. Cell Death Differ. 2008 Apr;15(4):718-29. View Related Products by Target MDM2-p53

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₃₅Cl₂N₅O₂

[ Molecular Weight ]:
592.565

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.