922150-12-7
922150-12-7 structure
- Name: P53R3
- Chemical Name: P53R3
- CAS Number: 922150-12-7
- Molecular Formula: C32H35Cl2N5O2
- Molecular Weight: 592.565
- Catalog: Signaling Pathways Apoptosis MDM-2/p53
- Create Date: 2020-01-20 10:42:57
- Modify Date: 2024-09-25 10:15:41
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P53R3 is a novel p53 reactivator that restores sequence-specific DNA binding of the endogenously expressed p53(R175H) and p53(R273H) mutants in gel-shift assays; induces p53-dependent antiproliferative effects with much higher specificity and over a wider range of concentrations than PRIMA-1; strongly enhances the mRNA, total protein and cell surface expression of DR5.
| Name | P53R3 |
|---|
| Description | P53R3 is a novel p53 reactivator that restores sequence-specific DNA binding of the endogenously expressed p53(R175H) and p53(R273H) mutants in gel-shift assays; induces p53-dependent antiproliferative effects with much higher specificity and over a wider range of concentrations than PRIMA-1; strongly enhances the mRNA, total protein and cell surface expression of DR5. |
|---|---|
| References | References 1. Weinmann L, et al. Cell Death Differ. 2008 Apr;15(4):718-29. View Related Products by Target MDM2-p53 |
| Molecular Formula | C32H35Cl2N5O2 |
|---|---|
| Molecular Weight | 592.565 |