MASM7

Modify Date: 2024-01-11 17:24:58

MASM7 Structure
MASM7 structure
Common Name MASM7
CAS Number 920868-45-7 Molecular Weight 453.58
Density N/A Boiling Point N/A
Molecular Formula C22H23N5O2S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MASM7


MASM7 is a mitofusin activator, and can achieve mitochondrial fusion via mitofusins[1].

 Names

Name MASM7

 MASM7 Biological Activity

Description MASM7 is a mitofusin activator, and can achieve mitochondrial fusion via mitofusins[1].
Related Catalog
In Vitro MASM7 increases Mito AR with an EC50 value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN. MASM7 demonstrates direct binding to the HR2 domain of MFN2 with Kd value of 1.1 μM. MASM7 does not induce DNA damage in any of the cell lines. MASM7 does not decrease cellular viability over the course of 72 h. MASM7 does not induce caspase-3/7 activation in U2OS cells. MASM7 concentration responsively increases mitochondrial membrane potential in WT MEFs[1].
References

[1]. Emmanouil Zacharioudakis, et al. Modulating mitofusins to control mitochondrial function and signaling. Nat Commun. 2022 Jul 7;13(1):3775.

 Chemical & Physical Properties

Molecular Formula C22H23N5O2S2
Molecular Weight 453.58
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