Lorediplon
Modify Date: 2025-08-22 22:32:57
Lorediplon structure
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Common Name | Lorediplon | ||
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| CAS Number | 917393-39-6 | Molecular Weight | 394.42200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H15FN4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LorediplonLorediplon is a novel non-benzodiazepine, hypnotic drug acting as a GABAA receptor modulator, differentially active at the alpha1-subunit, associated with promoting sleep.Target: GABALorediplon is a drug for the treatment of insomnia, has been successfully completed with a best-in-class efficacy profile in terms of maintaining sleep and sleep quality, Lorediplon targets GABAA. [1] Lorediplon demonstrates a minimum of 10-fold and 6-fold increase in potency (respectively) in the spontaneous motor activation studies. At concentrations of 1.2mg/kg, Lorediplon demonstrates a 57%increased effect on Slow Wave Sleep (SWS), when compared with a placebo.[2] |
| Name | N-[2-fluoro-5-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-N-methylacetamide |
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| Synonym | More Synonyms |
| Description | Lorediplon is a novel non-benzodiazepine, hypnotic drug acting as a GABAA receptor modulator, differentially active at the alpha1-subunit, associated with promoting sleep.Target: GABALorediplon is a drug for the treatment of insomnia, has been successfully completed with a best-in-class efficacy profile in terms of maintaining sleep and sleep quality, Lorediplon targets GABAA. [1] Lorediplon demonstrates a minimum of 10-fold and 6-fold increase in potency (respectively) in the spontaneous motor activation studies. At concentrations of 1.2mg/kg, Lorediplon demonstrates a 57%increased effect on Slow Wave Sleep (SWS), when compared with a placebo.[2] |
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| Related Catalog | |
| References |
| Molecular Formula | C20H15FN4O2S |
|---|---|
| Molecular Weight | 394.42200 |
| Exact Mass | 394.09000 |
| PSA | 95.81000 |
| LogP | 3.81060 |
| InChIKey | NQPOCLFSADOXBR-UHFFFAOYSA-N |
| SMILES | CC(=O)N(C)c1cc(-c2ccnc3c(C(=O)c4cccs4)cnn23)ccc1F |
| Lorediplon |
| N-(2-Fluoro-5-(3-(thiophene-2-carbonyl)pyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-methylacetamide |
| Lorediplon [INN] |
| Acetamide,N-(2-fluoro-5-(3-(2-thienylcarbonyl)pyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-methyl |
| UNII-VKU6Z23NSY |