Sarafloxacin hydrochloride

Modify Date: 2024-01-02 18:36:55

Sarafloxacin hydrochloride structure	Common Name	Sarafloxacin hydrochloride
	CAS Number	91296-87-6	Molecular Weight	421.83
	Density	1.4±0.1 g/cm3	Boiling Point	621.4±55.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₁₈ClF₂N₃O₃	Melting Point	275ºC
	MSDS	N/A	Flash Point	329.6±31.5 °C

Use of Sarafloxacin hydrochloride

Sarafloxacin hydrochloride is a quinolone antibiotic drug.Target: Antibacterialsarafloxacin hydrochloride is a fluoroquinolone antibiotic registered for use against poultry diseases. Sarafloxacin treatment demonstrated mineralization to 14CO2 amounting to 0.58%, 0.49%, and 0.57% in loam, silt loam, and sandy loam soils, respectively, at the termination of the test [1]. The inhibitory level of sarafloxacin for the tested bacteria was strain dependent. It appeared that in broth culture Escherichia coli isolates were sensitive to sarafloxacin concentrations 5-fold lower than the concentrations present in the simulated gut model, suggesting that sarafloxacin may be partially unavailable due to absorption to organic matter in the model [2]. Administering Sarafloxacin hydrochloride in the feed for 5 d at a dose of 10 or 12.5 mg/kg of fish proved efficacious in treating channel catfish infected with E. ictaluri in all three field trials. Average survival of the nonmedicated group was 43% in trial 1, 11°% in trial 2, and 59% in trial 3. Survival of the corresponding Sarafloxacin hydrochloride-medicated groups averaged 68, 48, and 73%. Antibiotic therapy with Sarafloxacin hydrochloride significantly (P < 0.05) improved survival in all trials [3].

Name	Sarafloxacin Hydrochloride
Synonym	More Synonyms

Description	Sarafloxacin hydrochloride is a quinolone antibiotic drug.Target: Antibacterialsarafloxacin hydrochloride is a fluoroquinolone antibiotic registered for use against poultry diseases. Sarafloxacin treatment demonstrated mineralization to 14CO2 amounting to 0.58%, 0.49%, and 0.57% in loam, silt loam, and sandy loam soils, respectively, at the termination of the test [1]. The inhibitory level of sarafloxacin for the tested bacteria was strain dependent. It appeared that in broth culture Escherichia coli isolates were sensitive to sarafloxacin concentrations 5-fold lower than the concentrations present in the simulated gut model, suggesting that sarafloxacin may be partially unavailable due to absorption to organic matter in the model [2]. Administering Sarafloxacin hydrochloride in the feed for 5 d at a dose of 10 or 12.5 mg/kg of fish proved efficacious in treating channel catfish infected with E. ictaluri in all three field trials. Average survival of the nonmedicated group was 43% in trial 1, 11°% in trial 2, and 59% in trial 3. Survival of the corresponding Sarafloxacin hydrochloride-medicated groups averaged 68, 48, and 73%. Antibiotic therapy with Sarafloxacin hydrochloride significantly (P < 0.05) improved survival in all trials [3].
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
References	[1]. Marengo, J.R., et al., Aerobic biodegradation of (14C)-sarafloxacin hydrochloride in soil. Environmental Toxicology and Chemistry, 1997. 16(3): p. 462-471. [2]. McConville, M.L., et al., Effects of sarafloxacin hydrochloride on human enteric bacteria under simulated human gut conditions. Vet Q, 1995. 17(1): p. 1-5. [3]. Johnson, M.R., K.L. Smith, and C.R. Boyle, Field efficacy trials of the antibacterial sarafloxacin-hydrochloride (A-56620) for treatment of Edwardsiella ictaluri infections in channel catfish. Journal of aquatic animal health, 1992. 4(4): p. 244-251.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

References

[1]. Marengo, J.R., et al., Aerobic biodegradation of (14C)-sarafloxacin hydrochloride in soil. Environmental Toxicology and Chemistry, 1997. 16(3): p. 462-471.

[2]. McConville, M.L., et al., Effects of sarafloxacin hydrochloride on human enteric bacteria under simulated human gut conditions. Vet Q, 1995. 17(1): p. 1-5.

[3]. Johnson, M.R., K.L. Smith, and C.R. Boyle, Field efficacy trials of the antibacterial sarafloxacin-hydrochloride (A-56620) for treatment of Edwardsiella ictaluri infections in channel catfish. Journal of aquatic animal health, 1992. 4(4): p. 244-251.

Density	1.4±0.1 g/cm3
Boiling Point	621.4±55.0 °C at 760 mmHg
Melting Point	275ºC
Molecular Formula	C₂₀H₁₈ClF₂N₃O₃
Molecular Weight	421.83
Flash Point	329.6±31.5 °C
PSA	74.57000
LogP	2.09
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.633
Storage condition	0-6°C

Sarafloxacin hydrochloride MSDS(Chinese)

Hazard Codes	Xn,Xi
Risk Phrases	R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S27-S36/37/39
WGK Germany	3
RTECS	CU7700000
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%