Decoglurant

Modify Date: 2025-08-24 22:02:44

Decoglurant Structure
Decoglurant structure
 Common Name Decoglurant
CAS Number 911115-16-7 Molecular Weight 447.33600
Density N/A Boiling Point N/A
Molecular Formula C21H11F6N5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Decoglurant


Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3. Decoglurant is developed as an antidepressant[1].

 Names

Name 5-[2-[7-(trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]ethynyl]pyridin-2-amine
Synonym More Synonyms

 Decoglurant Biological Activity

Description Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3. Decoglurant is developed as an antidepressant[1].
Related Catalog
Target

mGluR2

mGluR3

References

[1]. Wilkinson ST, et al. A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems. Drug Discov Today. 2019 Feb;24(2):606-615.

 Chemical & Physical Properties

Molecular Formula C21H11F6N5
Molecular Weight 447.33600
Exact Mass 447.09200
PSA 69.83000
LogP 4.74100
InChIKey DMJHZVARRXJSEG-UHFFFAOYSA-N
SMILES Nc1ccc(C#Cc2cnn3c(C(F)(F)F)cc(-c4ccc(C(F)(F)F)cc4)nc23)cn1

 Synonyms

Decoglurant
UNII-5VX4P0JKC5
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Related Compounds: More...
1-Isobutyl-1H-indazole-4-carboxylic acid methyl ester
1431310-47-2
2-Chloro-6-(trifluoromethyl)benzyl methanesulfonate
1562194-94-8
3-Ethyl-4-(methoxycarbonyl)benzoic acid
1561780-35-5
methyl 3-fluoro-4-(1H-pyrazolo[4,3-b]pyridin-3-yl)benzoate
1562194-90-4
4-(4-(4,6-Dimethylpyrimidin-5-YL)-3-methylphenoxy)-3-methylfuro[3,2-C]pyridine
1609577-45-8
4-((4-(1-Methyl-1H-pyrazol-5-YL)phenyl)thio)furo[3,2-C]pyridine tfa
1609577-18-5
5-(Furo[3,2-c]pyridin-4-yloxy)-2-(imidazo[1,2-a]pyridin-5-yl)aniline
1609577-32-3
2-Bromo-5-(furo[3,2-c]pyridin-4-yloxy)aniline
1609581-20-5
3-Bromo-6-(4-(furo[3,2-C]pyridin-4-yloxy)-2-methylphenyl)-5-methylpyrazin-2-amine
1609581-02-3
4-((benzyloxy)methoxy)-7-bromo-1-methyl-1H-indazole
1609581-57-8
Chemsrc provides Decoglurant(CAS#:911115-16-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Decoglurant are included as well.>> amp version: Decoglurant

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