911115-16-7

911115-16-7 structure

Name: Decoglurant
Chemical Name: 5-[2-[7-(trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]ethynyl]pyridin-2-amine
CAS Number: 911115-16-7
Molecular Formula: C₂₁H₁₁F₆N₅
Molecular Weight: 447.33600
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2017-09-07 08:52:35
Modify Date: 2025-08-24 22:02:44
Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3. Decoglurant is developed as an antidepressant[1].

Name	5-[2-[7-(trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]ethynyl]pyridin-2-amine
Synonyms	Decoglurant UNII-5VX4P0JKC5

Description	Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3. Decoglurant is developed as an antidepressant[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGluR2 mGluR3
References	[1]. Wilkinson ST, et al. A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems. Drug Discov Today. 2019 Feb;24(2):606-615.