Cl-HIBO

Modify Date: 2024-01-04 17:12:43

Cl-HIBO structure	Common Name	Cl-HIBO
	CAS Number	909400-43-7	Molecular Weight	206.58400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆H₇ClN₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Cl-HIBO

Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties[1].

Name	2-amino-3-(4-chloro-3-oxo-1,2-oxazol-5-yl)propanoic acid
Synonym	More Synonyms

Description	Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	EC50: 4.7, 1.7, 2700 and 1300 μM=GluR1/2/3/4[1]
In Vitro	Cl-HIBO is a strongly desensitizing full agonist at GluR1[1].
References	[1]. Bjerrum EJ, et al. Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). J Med Chem. 2003;46(11):2246-2249.

Molecular Formula	C₆H₇ClN₂O₄
Molecular Weight	206.58400
Exact Mass	206.00900
PSA	109.58000
LogP	0.68830

Cl-HIBO

4-CHLOROHOMOIBOTENIC ACID

DC Chemicals Limited
China
Product Name: Cl-HIBO
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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Cl-HIBO

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