R-999636

Modify Date: 2025-08-25 07:26:32

R-999636 Structure
R-999636 structure
Common Name R-999636
CAS Number 90833-53-7 Molecular Weight 395.238
Density 1.4±0.1 g/cm3 Boiling Point 535.7±45.0 °C at 760 mmHg
Molecular Formula C21H12Cl2N2O2 Melting Point N/A
MSDS N/A Flash Point 277.8±28.7 °C

 Use of R-999636


R-999636 is a small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 8.8 uM in FP assay; displays 5.8-fold and 7.8-fold selectivity over β-catenin/E-cadherin and β-catenin/APC interactions, respectively.

 Names

Name 2,3-Bis(4-chlorophenyl)-6-quinoxalinecarboxylic acid
Synonym More Synonyms

 R-999636 Biological Activity

Description R-999636 is a small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 8.8 uM in FP assay; displays 5.8-fold and 7.8-fold selectivity over β-catenin/E-cadherin and β-catenin/APC interactions, respectively.
References References 1. Zhang M, et al. ACS Med Chem Lett. 2013 Jan 8;4(2):306-11. View Related Products by Target Beta-catenin

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 535.7±45.0 °C at 760 mmHg
Molecular Formula C21H12Cl2N2O2
Molecular Weight 395.238
Flash Point 277.8±28.7 °C
Exact Mass 394.027588
LogP 5.11
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.693

 Synonyms

2,3-Bis(4-chlorophenyl)-6-quinoxalinecarboxylic acid
6-Quinoxalinecarboxylic acid, 2,3-bis(4-chlorophenyl)-
MFCD00555191
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