90833-53-7
90833-53-7 structure
- Name: R-999636
- Chemical Name: 2,3-Bis(4-chlorophenyl)-6-quinoxalinecarboxylic acid
- CAS Number: 90833-53-7
- Molecular Formula: C21H12Cl2N2O2
- Molecular Weight: 395.238
- Create Date: 2020-01-11 12:02:59
- Modify Date: 2025-08-25 07:26:32
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R-999636 is a small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 8.8 uM in FP assay; displays 5.8-fold and 7.8-fold selectivity over β-catenin/E-cadherin and β-catenin/APC interactions, respectively.
| Name | 2,3-Bis(4-chlorophenyl)-6-quinoxalinecarboxylic acid |
|---|---|
| Synonyms |
2,3-Bis(4-chlorophenyl)-6-quinoxalinecarboxylic acid
6-Quinoxalinecarboxylic acid, 2,3-bis(4-chlorophenyl)- MFCD00555191 |
| Description | R-999636 is a small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 8.8 uM in FP assay; displays 5.8-fold and 7.8-fold selectivity over β-catenin/E-cadherin and β-catenin/APC interactions, respectively. |
|---|---|
| References | References 1. Zhang M, et al. ACS Med Chem Lett. 2013 Jan 8;4(2):306-11. View Related Products by Target Beta-catenin |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 535.7±45.0 °C at 760 mmHg |
| Molecular Formula | C21H12Cl2N2O2 |
| Molecular Weight | 395.238 |
| Flash Point | 277.8±28.7 °C |
| Exact Mass | 394.027588 |
| LogP | 5.11 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.693 |