COH34
Modify Date: 2025-08-27 20:47:31
COH34 structure
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Common Name | COH34 | ||
|---|---|---|---|---|
| CAS Number | 906439-72-3 | Molecular Weight | 293.38 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H15NOS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of COH34COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1]. |
| Name | COH34 |
|---|
| Description | COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1]. |
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| Related Catalog | |
| Target |
IC50: 0.37 nM (PARG)[1] |
| In Vitro | COH34 efficiently kills PARP inhibitor-resistant cancer cells[1]. |
| In Vivo | COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models[1]. |
| References |
| Molecular Formula | C18H15NOS |
|---|---|
| Molecular Weight | 293.38 |
| InChIKey | SFUAIBHPGDRCFL-UHFFFAOYSA-N |
| SMILES | Cc1ccc(SN=Cc2c(O)ccc3ccccc23)cc1 |
| Storage condition | 2-8°C |