COH34

Names

[ Name ]:
COH34

Biological Activity

[Description]:

COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 0.37 nM (PARG)[1]

[In Vitro]

COH34 efficiently kills PARP inhibitor-resistant cancer cells[1].

[In Vivo]

COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models[1].

[References]

[1]. Chen SH, et al. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5(4):eaav4340.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₅NOS

[ Molecular Weight ]:
293.38

[ Storage condition ]:
2-8°C

Related Compounds

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