906439-72-3

906439-72-3 structure

Name: COH34
Chemical Name: COH34
CAS Number: 906439-72-3
Molecular Formula: C₁₈H₁₅NOS
Molecular Weight: 293.38
Catalog: Research Areas Cancer
Create Date: 2019-12-08 21:34:19
Modify Date: 2025-08-27 20:47:31
COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1].

Name	COH34

Description	COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 0.37 nM (PARG)[1]
In Vitro	COH34 efficiently kills PARP inhibitor-resistant cancer cells[1].
In Vivo	COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models[1].
References	[1]. Chen SH, et al. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5(4):eaav4340.