LIMK1 inhibitor BMS-4
Modify Date: 2024-01-17 21:56:08
LIMK1 inhibitor BMS-4 structure
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Common Name | LIMK1 inhibitor BMS-4 | ||
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| CAS Number | 905298-84-2 | Molecular Weight | 461.53900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H23N7O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LIMK1 inhibitor BMS-4LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells[1][2]. |
| Name | 1-Ethyl-3-{5-[6-(4-methoxy-2,6-dimethylphenyl)-2-(2-pyrazinyl)-4- pyrimidinyl]-1,3-thiazol-2-yl}ure |
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| Description | LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells[1][2]. |
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| Related Catalog | |
| Target |
LIMK1:7.25 (pIC50) LIMK2:6.87 (pIC50) |
| In Vitro | LIMK1 inhibitor BMS-4 (compound 4) (0.014-10 μM; 24 h) 在体外抑制 LIMK 而不影响 A549 细胞存活或增殖[1]。 LIMK1 inhibitor BMS-4 (0.014-1 μM; 2 h) 在 A549 人肺癌细胞中抑制 LIMK 底物 cofilin 的磷酸化[1]。 |
| References |
| Molecular Formula | C23H23N7O2S |
|---|---|
| Molecular Weight | 461.53900 |
| Exact Mass | 461.16300 |
| PSA | 146.54000 |
| LogP | 4.76830 |