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708992-34-1

708992-34-1 structure

708992-34-1 structure

Name: SIRT5 inhibitor 4
Chemical Name: SIRT5 inhibitor 4
CAS Number: 708992-34-1
Molecular Formula: C₁₈H₁₅N₃O₄S
Molecular Weight: 369.39
Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
Create Date: 2022-09-01 09:43:14
Modify Date: 2025-08-23 13:20:12
SIRT5 inhibitor 4 (compound 11) is a potent, selective SIRT5 inhibitor with IC50 values of 26.4 and >400μM for SIRT5 and other SIRT subtype, respectively[1].

Name	SIRT5 inhibitor 4

Description	SIRT5 inhibitor 4 (compound 11) is a potent, selective SIRT5 inhibitor with IC50 values of 26.4 and >400μM for SIRT5 and other SIRT subtype, respectively[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Target	SIRT5:26.4 μM (IC50) SIRT1:＞400 μM (IC50) SIRT2:＞400 μM (IC50) SIRT3:＞400 μM (IC50) SIRT6:＞400 μM (IC50) SIRT7:＞400 μM (IC50)
In Vitro	SIRT5 inhibitor 4 (compound 11) (6-200 µM) stabilizes SIRT5 protein with a temperature shift of 1.8℃ in a dose-dependent manner[1].
References	[1]. Han LY, et, al. Identification of 2-hydroxybenzoic acid derivatives as selective SIRT5 inhibitors. Eur.J.Med.Chem.2022 Jul 22, 114623

Molecular Formula	C₁₈H₁₅N₃O₄S
Molecular Weight	369.39

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