3alpha-hydroxysteroid dehydrogenase

Modify Date: 2025-08-25 22:50:38

3alpha-hydroxysteroid dehydrogenase structure	Common Name	3alpha-hydroxysteroid dehydrogenase
	CAS Number	9028-56-2	Molecular Weight	N/A
	Density	N/A	Boiling Point	N/A
	Molecular Formula	N/A	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of 3alpha-hydroxysteroid dehydrogenase

3α-Hydroxysteroid dehydrogenase (3α-HSD) is an enzyme encoded by the AKR1C4 gene, which can catalyze the conversion of 3-ketosteroids into 3α-hydroxy compounds. 3α-Hydroxysteroid dehydrogenase plays an important role in the inactivation of androgen DHT, and can convert DHT into 3α-androstanediol with weak androgen activity, which can be used in the research of hirsutism[1].

Name	Dehydrogenase 3alpha-hydroxy steroid
Synonym	More Synonyms

Description	3α-Hydroxysteroid dehydrogenase (3α-HSD) is an enzyme encoded by the AKR1C4 gene, which can catalyze the conversion of 3-ketosteroids into 3α-hydroxy compounds. 3α-Hydroxysteroid dehydrogenase plays an important role in the inactivation of androgen DHT, and can convert DHT into 3α-androstanediol with weak androgen activity, which can be used in the research of hirsutism[1].
Related Catalog	Research Areas >> Endocrinology
References	[1]. Anne Z Steiner, et al. 3alpha-Hydroxysteroid dehydrogenase type III deficiency: a novel mechanism for hirsutism. J Clin Endocrinol Metab. 2008 Apr;93(4):1298-303.

Appearance of Characters	ammonium sulfate suspension
InChIKey	WZWONBSCKCYGIW-UHFFFAOYSA-N
SMILES	O=C1C(=O)c2ccccc2C1=Cc1cc2c(s1)C1=CC3C=C4C(=CC3C=C1C21CCCCC1)c1sc(C=C2C(=O)C(=O)c3ccccc32)cc1C41CCCCC1
Storage condition	2-8°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
WGK Germany	3

Electronic effects of para-substitution on acetophenones in the reaction of rat liver 3alpha-hydroxysteroid dehydrogenase.

Bioorg. Med. Chem. 16 , 1084-9, (2008)

Stereoselective reductive metabolism of various p-substituted acetophenone derivatives was studied using isolated rat liver 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD). Kinetic experiments were p...

Enzyme biosensor for androsterone based on 3α-hydroxysteroid dehydrogenase immobilized onto a carbon nanotubes/ionic liquid/NAD+ composite electrode.

Talanta 99 , 697-702, (2012)

A 3α-hydrosteroid biosensor for androsterone determination has been prepared by immobilizing the enzyme 3α-hydroxysteroid dehydrogenase (3α-HSD) in a composite electrode platform constituted of a mixt...

Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase.

Biochem. Biophys. Res. Commun. 148(2) , 646-52, (1987)

Homogeneous 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) from rat liver cytosol displays 9, 11, and 15-hydroxyprostaglandin dehydrogenase activity. Using [14C]-PGF2 alpha as substrate the produc...

ALPHA-HYDROXYSTEROID DEHYDROGENASE

3ALPHA-HYDROXYSTEROID: NAD[P]+ OXIDOREDUCTASE

EC 1.1.1.50

EC: 1.1.1.50

3alpha-hydroxysteroid dehydrogenase F. pseu. test. ~9 U/mg

3alpha-Hydroxysteroid Dehydrogenase from Pseudomonas testosteroni

Dehydrogenase, 3alpha-hydroxy steroid