Ethyl cellulose

Modify Date: 2024-01-02 21:02:49

Ethyl cellulose Structure
Ethyl cellulose structure
 Common Name Ethyl cellulose
CAS Number 9004-57-3 Molecular Weight 448.474
Density 1.45 Boiling Point 654.2±55.0 °C at 760 mmHg
Molecular Formula C23H24N6O4 Melting Point 240-255ºC
MSDS Chinese USA Flash Point 349.5±31.5 °C

 Use of Ethyl cellulose


Ethyl cellulose is a derivative of cellulose. Ethyl cellulose serves as a non-toxic and biodegradable polymer, with unique properties such as oleogel formation, delivery of active component, and film-forming ability in the food and pharmaceutical sectors. Ethyl cellulose can be used as an excipient, such as coating agent, flavoring agent, tablet filler. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

 Names

Name Ethyl cellulose
Synonym More Synonyms

 Ethyl cellulose Biological Activity

Description Ethyl cellulose is a derivative of cellulose. Ethyl cellulose serves as a non-toxic and biodegradable polymer, with unique properties such as oleogel formation, delivery of active component, and film-forming ability in the food and pharmaceutical sectors. Ethyl cellulose can be used as an excipient, such as coating agent, flavoring agent, tablet filler. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog
References

[1]. Ahmadi P, Jahanban-Esfahlan A, Ahmadi A, et al. Development of ethyl cellulose-based formulations: A perspective on the novel technical methods[J]. Food Reviews International, 2022, 38(4): 685-732.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

 Chemical & Physical Properties

Density 1.45
Boiling Point 654.2±55.0 °C at 760 mmHg
Melting Point 240-255ºC
Molecular Formula C23H24N6O4
Molecular Weight 448.474
Flash Point 349.5±31.5 °C
Exact Mass 448.185913
PSA 147.66000
LogP 6.62
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.14
Storage condition room temp
Water Solubility insoluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FJ5950500
CHEMICAL NAME :
Cellulose, ethyl ether
CAS REGISTRY NUMBER :
9004-57-3
LAST UPDATED :
199710

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 19,97,1981 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 19,113,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 19,113,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82229 No. of Facilities: 10802 (estimated) No. of Industries: 130 No. of Occupations: 90 No. of Employees: 98834 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5864 No. of Facilities: 6051 (estimated) No. of Industries: 79 No. of Occupations: 80 No. of Employees: 74759 (estimated) No. of Female Employees: 27837 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS FJ5950500

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 Synonyms

1,3-Benzenedicarbonitrile, 2-((4-((2-(acetyloxy)ethyl)butylamino)-2-methylphenyl)azo)-5-nitro-
EINECS 232-674-9
2-(Butyl{4-[(E)-(2,6-dicyano-4-nitrophenyl)diazenyl]-3-methylphenyl}amino)ethyl acetate
2-(Butyl{4-[(E)-(2,6-dicyano-4-nitrophenyl)diazenyl]-3-methylphen yl}amino)ethyl acetate
1,3-Benzenedicarbonitrile, 2-[(E)-2-[4-[[2-(acetyloxy)ethyl]butylamino]-2-methylphenyl]diazenyl]-5-nitro-
MFCD00131037
n-butyl-n-(2-acetoxyethyl)-4-((4-nitro-2,6-dicyanophenyl)azo)-3-methylbenzeneamine
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