(S)-Mapracorat
Modify Date: 2024-01-09 16:04:41
(S)-Mapracorat structure
|
Common Name | (S)-Mapracorat | ||
|---|---|---|---|---|
| CAS Number | 887375-15-7 | Molecular Weight | 462.48 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H26F4N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (S)-Mapracorat(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist. |
| Name | (S)-Mapracorat |
|---|
| Description | (S)-Mapracorat is a selective and less active glucocorticoid receptor agonist. |
|---|---|
| Related Catalog | |
| In Vitro | (S)-Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM. |
| In Vivo | Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas. |
| References |
| Molecular Formula | C25H26F4N2O2 |
|---|---|
| Molecular Weight | 462.48 |
| InChIKey | VJGFOYBQOIPQFY-DEOSSOPVSA-N |
| SMILES | Cc1ccc2c(NCC(O)(CC(C)(C)c3cc(F)cc4c3OCC4)C(F)(F)F)cccc2n1 |