(S)-Mapracorat

Names

[ CAS No. ]:
887375-15-7

[ Name ]:
(S)-Mapracorat

Biological Activity

[Description]:

(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor

[In Vitro]

(S)-Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM.

[In Vivo]

Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas.

[References]

[1]. Bäumer W , et al. The selective glucocorticoid receptor agonist mapracorat displays a favourable safety-efficacy ratio for the topical treatment of inflammatory skin diseases in dogs. Vet Dermatol. 2017 Feb; 28(1):46-e11.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₆F₄N₂O₂

[ Molecular Weight ]:
462.48

Related Compounds

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