H-D-Pro-Phe-Arg-chloromethylketone trifluoroacetate salt

Modify Date: 2024-01-17 08:06:12

H-D-Pro-Phe-Arg-chloromethylketone trifluoroacetate salt Structure
H-D-Pro-Phe-Arg-chloromethylketone trifluoroacetate salt structure
Common Name H-D-Pro-Phe-Arg-chloromethylketone trifluoroacetate salt
CAS Number 88546-74-1 Molecular Weight 450.96200
Density N/A Boiling Point N/A
Molecular Formula C21H31ClN6O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of H-D-Pro-Phe-Arg-chloromethylketone trifluoroacetate salt


D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma kallikrein, plays an important role in thrombosis and inflammation[1].

 Names

Name (2R)-N-[(2S)-1-[[(3S)-1-chloro-6-(diaminomethylideneamino)-2-oxohexan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
Synonym More Synonyms

  Biological Activity

Description D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma kallikrein, plays an important role in thrombosis and inflammation[1].
Related Catalog
References

[1]. Katrin F Nickel, et al. Factor XII as a Therapeutic Target in Thromboembolic and Inflammatory Diseases. Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):13-20.  

 Chemical & Physical Properties

Molecular Formula C21H31ClN6O3
Molecular Weight 450.96200
Exact Mass 450.21500
PSA 149.20000
LogP 2.32340

 Synonyms

D-Pro-Phe-Arg chloromethyl ketone
D-Pro-Phe-Arg chloromethyl ketone (PCK)
L-Phenylalaninamide,D-prolyl-N-[4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-,(S)
H-D-Pro-Phe-Arg-chloromethylketone
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