H-D-Pro-Phe-Arg-chloromethylketone trifluoroacetate salt

Names

[ Name ]:
H-D-Pro-Phe-Arg-chloromethylketone trifluoroacetate salt

[Synonym ]:
D-Pro-Phe-Arg chloromethyl ketone
D-Pro-Phe-Arg chloromethyl ketone (PCK)
L-Phenylalaninamide,D-prolyl-N-[4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-,(S)
H-D-Pro-Phe-Arg-chloromethylketone

Biological Activity

[Description]:

D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma kallikrein, plays an important role in thrombosis and inflammation[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Research Areas >> Neurological Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa

[References]

[1]. Katrin F Nickel, et al. Factor XII as a Therapeutic Target in Thromboembolic and Inflammatory Diseases. Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):13-20.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₃₁ClN₆O₃

[ Molecular Weight ]:
450.96200

[ Exact Mass ]:
450.21500

[ PSA ]:
149.20000

[ LogP ]:
2.32340

Related Compounds

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