HJC 0350

Modify Date: 2024-01-31 10:13:51

HJC 0350 structure	Common Name	HJC 0350
	CAS Number	885434-70-8	Molecular Weight	277.38200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₉NO₂S	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of HJC 0350

HJC0350 is a potent and specific EPAC2 antagonist with an IC50 of 0.3 µM.

Name	2,4-dimethyl-1-(2,4,6-trimethyl-benzenesulfonyl)-1H-pyrrole
Synonym	More Synonyms

Description	HJC0350 is a potent and specific EPAC2 antagonist with an IC50 of 0.3 µM.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
Target	IC50: 0.3 µM (EPAC2)[1]
In Vitro	HJC0350 has an apparent IC50 value of 0.3 µM for competing with 8-NBD-cAMP binding of EPAC2, and is about 133-fold more potent than cAMP. HJC0350 is found not to inhibit EPAC1-mediated Rap1-GDP exchange activity at 25 µM in the presence of equal concentration of cAMP, indicating that it is EPAC2-specific antagonists. Pretreatment of HEK293/EPAC2-FL cells with 10 µM HJC0350 fully blocks the 007-AM induced decrease of FRET[1].
References	[1]. Chen H, et al. Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J Med Chem. 2013 Feb 14;56(3):952-62.

Molecular Formula	C₁₅H₁₉NO₂S
Molecular Weight	277.38200
Exact Mass	277.11400
PSA	47.45000
LogP	4.34790
Storage condition	-20℃

Hazard Codes	N
RIDADR	NONH for all modes of transport

HJC0350

HJC-0350

DC Chemicals Limited
China
Product Name: HJC-0350
Price: $400.0/100mg $700.0/250mg $1350.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $77/10mM*1mLinDMSO

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