1417718-39-8
1417718-39-8 structure
- Name: HJC-0338
- Chemical Name: N-(2,5-Dichlorophenyl)-2,4,6-trimethylaniline
- CAS Number: 1417718-39-8
- Molecular Formula: C15H15Cl2N
- Molecular Weight: 280.192
- Create Date: 2020-01-20 11:31:57
- Modify Date: 2024-10-06 13:30:56
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HJC-0338 is a potent and specific EPAC2 antagonist with IC50 of 0.4 uM for competing with 8-NBD-cAMP in binding EPAC2; exhibits no inhibition of EPAC1-mediated Rap1-GDP exchange activity at 25 uM; selectively block cAMP-induced EPAC2 activation but do not inhibit cAMP-mediated PKA activation.
| Name | N-(2,5-Dichlorophenyl)-2,4,6-trimethylaniline |
|---|---|
| Synonyms |
Benzenamine, N-(2,5-dichlorophenyl)-2,4,6-trimethyl-
N-(2,5-Dichlorophenyl)-2,4,6-trimethylaniline |
| Description | HJC-0338 is a potent and specific EPAC2 antagonist with IC50 of 0.4 uM for competing with 8-NBD-cAMP in binding EPAC2; exhibits no inhibition of EPAC1-mediated Rap1-GDP exchange activity at 25 uM; selectively block cAMP-induced EPAC2 activation but do not inhibit cAMP-mediated PKA activation. |
|---|---|
| References | References 1. Chen H, et al. J Med Chem. 2013 Feb 14;56(3):952-62. View Related Products by Target Other Targets |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 355.9±42.0 °C at 760 mmHg |
| Molecular Formula | C15H15Cl2N |
| Molecular Weight | 280.192 |
| Flash Point | 169.0±27.9 °C |
| Exact Mass | 279.058167 |
| LogP | 6.07 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.617 |