Mpro inhibitor N3
Modify Date: 2025-09-12 10:38:39
Mpro inhibitor N3 structure
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Common Name | Mpro inhibitor N3 | ||
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| CAS Number | 884650-98-0 | Molecular Weight | 680.8 | |
| Density | 1.192±0.06 g/cm3(Predicted) | Boiling Point | 990.8±65.0 °C(Predicted) | |
| Molecular Formula | C35H48N6O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Mpro inhibitor N3Mpro inhibitor N3 is a potent SARS-CoV-2 MPro inhibitor with an EC50 value of 16.77 µM. Mpro inhibitor N3 shows antiviral activities against HCoV-229E, FIPV, IBV and MHV-A59[1][2][3]. |
| Name | MPro N3 |
|---|---|
| Synonym | More Synonyms |
| Description | Mpro inhibitor N3 is a potent SARS-CoV-2 MPro inhibitor with an EC50 value of 16.77 µM. Mpro inhibitor N3 shows antiviral activities against HCoV-229E, FIPV, IBV and MHV-A59[1][2][3]. |
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| Related Catalog | |
| In Vitro | Mpro inhibitor N3 (0-100 µM) 具有抗病毒活性，对 SARS-CoV-2 的 EC50 值为 16.77 µM[1]。 Mpro inhibitor N3 (0-50 µM; 14 h) 抑制病毒生长，对 HCoV-229E、FIPV 和 MHV-A59 的 IC50 值分别为 4、8.8、2.7 µM[2]。 |
| In Vivo | Mpro inhibitor N3 (0-0.64 µM; 3, 6 h) 在鸡胚胎中表现出抗 IBV 的抗病毒活性[3]。 Animal Model: Chicken embryos[3] Dosage: 0-0.64 µM Administration: 3, 6 h with 100-EID50 titer of IBV M41 virus Result: Showed that N3 is able to penetrate cells to inhibit the replication of IBV viruses, probably at the beginning of infection, with the PD50 of 0.13 μmol for the 3-h group and 0.17 μmol for the 6-h group. |
| References |
| Density | 1.192±0.06 g/cm3(Predicted) |
|---|---|
| Boiling Point | 990.8±65.0 °C(Predicted) |
| Molecular Formula | C35H48N6O8 |
| Molecular Weight | 680.8 |
| InChIKey | IDBWWEGDLCFCTD-VNEMRZQUSA-N |
| SMILES | Cc1cc(C(=O)NC(C)C(=O)NC(C(=O)NC(CC(C)C)C(=O)NC(C=CC(=O)OCc2ccccc2)CC2CCNC2=O)C(C)C)no1 |
| N-[(5-Methyl-3-isoxazolyl)carbonyl]-L-alanyl-L-valyl-N-[(1S,2E)-4-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]-4-(phenylmethoxy)-2-buten-1-yl]-L-leucinamide |