A2793

Modify Date: 2025-08-26 21:28:18

Use of A2793

A2793 is an efficient TWIK-related acid-sensitive K+ channel (TASK)-1 inhibitor, with an IC50 of 6.8 μM[1].

Name	ethyl 2-(5-chloroquinolin-8-yl)oxyacetate
Synonym	More Synonyms

Description	A2793 is an efficient TWIK-related acid-sensitive K+ channel (TASK)-1 inhibitor, with an IC50 of 6.8 μM[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vitro	A2793 (100 µM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5)[1]. A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1[1].
References	[1]. Miklós Lengyel, et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K 2P 18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660.

Density	1.291±0.06 g/cm3
Boiling Point	393.4±27.0 °C
Molecular Formula	C₁₃H₁₂ClNO₃
Molecular Weight	265.69200
Exact Mass	265.05100
PSA	48.42000
LogP	2.83010
InChIKey	JEMXUSHXYOXNFL-UHFFFAOYSA-N
SMILES	CCOC(=O)COc1ccc(Cl)c2cccnc12
Storage condition	-20°C

Hazard Codes	Xn

MFCD04275530

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Price: ￥1650/10 mM * 1 mL in DMSO

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