Amlodipine

Modify Date: 2024-01-02 17:48:57

Amlodipine Structure
Amlodipine structure
 Common Name Amlodipine
CAS Number 88150-42-9 Molecular Weight 408.876
Density 1.2±0.1 g/cm3 Boiling Point 527.2±50.0 °C at 760 mmHg
Molecular Formula C20H25ClN2O5 Melting Point 178-179ºC
MSDS N/A Flash Point 272.6±30.1 °C

 Use of Amlodipine


Amlodipine is a long-acting calcium channel blocker.Target: Calcium ChannelAmlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. Experimental data suggest amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects, or decreased heart muscle contractility, can be detected in vitro, but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound (pKa = 8.6), and its interaction with the calcium channel receptor is characterized by a gradual rate of association and dissociation with the receptor binding site, resulting in a gradual onset of effect. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. From Wikipedia.

 Names

Name amlodipine
Synonym More Synonyms

 Amlodipine Biological Activity

Description Amlodipine is a long-acting calcium channel blocker.Target: Calcium ChannelAmlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. Experimental data suggest amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects, or decreased heart muscle contractility, can be detected in vitro, but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound (pKa = 8.6), and its interaction with the calcium channel receptor is characterized by a gradual rate of association and dissociation with the receptor binding site, resulting in a gradual onset of effect. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. From Wikipedia.
Related Catalog
References

[1]. http://en.wikipedia.org/wiki/Amlodipine

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 527.2±50.0 °C at 760 mmHg
Melting Point 178-179ºC
Molecular Formula C20H25ClN2O5
Molecular Weight 408.876
Flash Point 272.6±30.1 °C
Exact Mass 408.145203
PSA 99.88000
LogP 4.16
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.546
Storage condition -20°C Freezer
Water Solubility 75.3 mg/L

 Safety Information

Hazard Codes Xi
HS Code 2942000000

 Synthetic Route

Amlodipine besylate structure

Amlodipine besylate

CAS#:111470-99-6

~90%

Amlodipine Structure

Amlodipine

CAS#:88150-42-9
Literature: SELAMINE LTD Patent: WO2008/65424 A1, 2008 ; Location in patent: Page/Page column 33 ;
Amlodipine intermediate structure

Amlodipine inte...

CAS#:88150-62-3

~90%

Amlodipine Structure

Amlodipine

CAS#:88150-42-9
Literature: MATRIX LABORATORIES LTD Patent: WO2006/3672 A1, 2006 ; Location in patent: Page/Page column 7 ;
3-O-ethyl 5-O-methyl 2-(2-azidoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate structure

3-O-ethyl 5-O-m...

CAS#:88150-46-3

~%

Amlodipine Structure

Amlodipine

CAS#:88150-42-9
Literature: Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702
Ethyl 2-Chloroacetoacetate structure

Ethyl 2-Chloroa...

CAS#:638-07-3

~%

Amlodipine Structure

Amlodipine

CAS#:88150-42-9
Literature: Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702
ETHYL (2-AZIDOETHOXY)ACETOACETATE structure

ETHYL (2-AZIDOE...

CAS#:88150-45-2

~%

Amlodipine Structure

Amlodipine

CAS#:88150-42-9
Literature: Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702
2-(2-azidoethoxy)methyl-5-carboxy-4-(2-chlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine structure

2-(2-azidoethox...

CAS#:120289-15-8

~%

Amlodipine Structure

Amlodipine

CAS#:88150-42-9
Literature: Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702
Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate structure

Ethyl 4-(2-(1,3...

CAS#:88150-75-8

~%

Amlodipine Structure

Amlodipine

CAS#:88150-42-9
Literature: Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702

 Customs

HS Code 2942000000

 Synonyms

Norvasc
Lipinox
Amlodis
3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
T6M DHJ B1O2Z CVO2 DR BG& EVO1 F1
2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl Ester
UNII:1J444QC288
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
3-Ethyl 5-methyl 2-{[(2-aminoethyl)oxy]methyl}-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Amlodipino
3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
3-ethyl 5-methyl ()-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridine dicarboxylate
Istin
(R,S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
Amlodipinum [Latin]
Amlodipinum
Amlocard
Amlodipine
3-ethyl-5-methyl-(4RS)-2-[(2-aminoethoxy)-methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-carboxylate benzene sulphonate
MFCD00864687
3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate
Coroval
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Related Compounds: More...
Amlodipine
103129-82-4
d-Amlodipine
103129-81-3
S-Amlodipine
150566-71-5
l-Amlodipine-d4
1346616-97-4
amlodipine adipate
526216-43-3
amlodipine nitrate
246852-13-1
amlodipine acetate
246852-10-8
Amlodipine maleate
88150-47-4
amlodipine formate
246852-08-4
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