N-trifluoroacetyl-β-alanyl chloride

Modify Date: 2024-01-09 16:27:29

N-trifluoroacetyl-β-alanyl chloride structure	Common Name	N-trifluoroacetyl-β-alanyl chloride
	CAS Number	87639-76-7	Molecular Weight	203.54700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅H₅ClF₃NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of N-trifluoroacetyl-β-alanyl chloride

N-trifluoroacetyl-β-alanyl chloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name	3-[(2,2,2-trifluoroacetyl)amino]propanoyl chloride
Synonym	More Synonyms

Description	N-trifluoroacetyl-β-alanyl chloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Molecular Formula	C₅H₅ClF₃NO₂
Molecular Weight	203.54700
Exact Mass	202.99600
PSA	49.66000
LogP	1.66070

3-[(2,2,2-trifl...

CAS#:50632-82-1

~98%

N-trifluoroacet...

CAS#:87639-76-7

Literature: Gani, David; Young, Douglas W. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1355 - 1362