N-trifluoroacetyl-β-alanyl chloride

Names

[ Name ]:
N-trifluoroacetyl-β-alanyl chloride

[Synonym ]:
Propanoyl chloride,3-[(trifluoroacetyl)amino]

Biological Activity

[Description]:

N-trifluoroacetyl-β-alanyl chloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅H₅ClF₃NO₂

[ Molecular Weight ]:
203.54700

[ Exact Mass ]:
202.99600

[ PSA ]:
49.66000

[ LogP ]:
1.66070

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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