Disoxaril

Modify Date: 2024-01-13 20:45:35

Disoxaril Structure
Disoxaril structure
Common Name Disoxaril
CAS Number 87495-31-6 Molecular Weight 342.43200
Density 1.15g/cm3 Boiling Point 522.1ºC at 760 mmHg
Molecular Formula C20H26N2O3 Melting Point N/A
MSDS N/A Flash Point 269.6ºC

 Use of Disoxaril


A picornavirus replication inhibitor by binding to the hydrophobic pocket within the VP1 coat protein, thus stabilizing the virion and blocking its uncoating..

 Names

Name 5-[7-[4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]heptyl]-3-methyl-1,2-oxazole
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.15g/cm3
Boiling Point 522.1ºC at 760 mmHg
Molecular Formula C20H26N2O3
Molecular Weight 342.43200
Flash Point 269.6ºC
Exact Mass 342.19400
PSA 56.85000
LogP 3.76740
Index of Refraction 1.568

 Synthetic Route

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Disoxaril Structure

Disoxaril

CAS#:87495-31-6

Literature: Sterling Drug Inc. Patent: US4843087 A1, 1989 ;

~76%

Disoxaril Structure

Disoxaril

CAS#:87495-31-6

Literature: Diana, Guy D.; Oglesby, Richard C.; Akullian, Vahan; Carabateas, Phillip M.; Cutcliffe, David; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 383 - 388

~%

Disoxaril Structure

Disoxaril

CAS#:87495-31-6

Literature: Diana; McKinlay; Otto; Akullian; Oglesby Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910

~%

Disoxaril Structure

Disoxaril

CAS#:87495-31-6

Literature: Diana; McKinlay; Otto; Akullian; Oglesby Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910

~%

Disoxaril Structure

Disoxaril

CAS#:87495-31-6

Literature: Diana; McKinlay; Otto; Akullian; Oglesby Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910

~%

Disoxaril Structure

Disoxaril

CAS#:87495-31-6

Literature: Diana; McKinlay; Otto; Akullian; Oglesby Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910

~%

Disoxaril Structure

Disoxaril

CAS#:87495-31-6

Literature: Diana; McKinlay; Otto; Akullian; Oglesby Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910

~%

Disoxaril Structure

Disoxaril

CAS#:87495-31-6

Literature: Diana; McKinlay; Otto; Akullian; Oglesby Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1906 - 1910

 Synonyms

DISOXARIL
Disoxarilo [Spanish]
Disoxarilum [Latin]
5-{7-[4-(4,5-dihydro-2-oxazolyl)phenoxy]-heptyl}-3-methylisoxazole
Compound IV
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