Structure-activity studies of 5-[[4-(4, 5-dihydro-2-oxazolyl) phenoxy] alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating

…, V Akullian, PM Carabateas, D Cutcliffe…

Index: Diana, Guy D.; Oglesby, Richard C.; Akullian, Vahan; Carabateas, Phillip M.; Cutcliffe, David; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 383 - 388

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Citation Number: 35

Abstract

The mode of action of compound 1 has been shown to be the inhibition of viral uncoating. 6 The role of uncoating in the replication of picornaviruses is graphically shown in Figure 1. After receptor-mediated adsorption of the virus to the cell membrane, the virion penetrates ...

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Phenol, 4-(4,5-...

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5-[5-[4-(4,5-dihydro-1,3-oxazol-2-yl)-3-methylphenoxy]pentyl]-3-methyl-1,2-oxazole Structure

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4-(4,5-dihydroo...

~65%

5-[5-[4-(4,5-dihydro-1,3-oxazol-2-yl)-2-ethylphenoxy]pentyl]-3-methyl-1,2-oxazole Structure

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~27%

5-[5-[2-(difluoromethyl)-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl]-3-methyl-1,2-oxazole Structure

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5-[5-[2-(difluoromethyl)-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl]-3-methyl-1,2-oxazole Structure

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N/A Structure

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5-[4-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]butyl]-3-methyl-1,2-oxazole Structure

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5-[5-[4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl]-3-methyl-1,2-oxazole Structure

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~24%

5-[5-[4-(4,5-dihydro-1,3-oxazol-2-yl)-2-nitrophenoxy]pentyl]-3-methyl-1,2-oxazole Structure

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19013-10-6

ethyl 4-hydroxy...

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5-[5-[4-(4,5-dihydro-1,3-oxazol-2-yl)-2-nitrophenoxy]pentyl]-3-methyl-1,2-oxazole Structure

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Phenol, 4-(4,5-dihydro-2-oxazolyl) Structure

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~42%

5-[5-[2-bromo-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl]-3-methyl-1,2-oxazole Structure

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3-BROMO-2-CHLORO-5-PICOLINE Structure

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5-[5-[2-bromo-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl]-3-methyl-1,2-oxazole Structure

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~71%

5-(4,5-dihydro-1,3-oxazol-2-yl)-2-[5-(3-methyl-1,2-oxazol-5-yl)pentoxy]benzaldehyde Structure

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5-[6-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]hexyl]-3-methyl-1,2-oxazole Structure

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N/A Structure

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5-[5-[4-(4,5-dihydro-1,3-oxazol-2-yl)-2-propan-2-ylphenoxy]pentyl]-3-methyl-1,2-oxazole Structure

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