AMG-Tie2-1
Modify Date: 2025-09-06 06:44:13
AMG-Tie2-1 structure
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Common Name | AMG-Tie2-1 | ||
|---|---|---|---|---|
| CAS Number | 870223-96-4 | Molecular Weight | 479.454 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C25H20F3N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AMG-Tie2-1AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGF receptor 2 (VEGFR2) with IC50 values of 1 and 3 nM, respectively. |
| Name | 4-methyl-3-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxy-N-[3-(trifluoromethyl)phenyl]benzamide |
|---|---|
| Synonym | More Synonyms |
| Description | AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGF receptor 2 (VEGFR2) with IC50 values of 1 and 3 nM, respectively. |
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| Related Catalog |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C25H20F3N5O2 |
| Molecular Weight | 479.454 |
| Exact Mass | 479.156921 |
| PSA | 95.75000 |
| LogP | 4.78 |
| Index of Refraction | 1.630 |
| InChIKey | ZVIWALRWYYSHSU-UHFFFAOYSA-N |
| SMILES | CNc1nccc(-c2cccnc2Oc2cc(C(=O)Nc3cccc(C(F)(F)F)c3)ccc2C)n1 |
| 4-methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)-N-(3-(trifluoromethyl)phenyl)benzamide |
| AMG-Tie2 |
| 4-Methyl-3-({3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl}oxy)-N-[3-(trifluoromethyl)phenyl]benzamide |
| 4-methyl-3-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)-N-[3-(trifluoromethyl)phenyl]benzamide |
| pyridylpyrimidine ether 4 |
| AMG-Tie2-1 |
| Benzamide, 4-methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]- |