HDSF

Modify Date: 2025-09-01 18:20:47

HDSF Structure
HDSF structure
Common Name HDSF
CAS Number 86855-26-7 Molecular Weight 308.49500
Density 0.966g/cm3 Boiling Point 388.3ºC at 760 mmHg
Molecular Formula C16H33FO2S Melting Point N/A
MSDS N/A Flash Point 188.6ºC

 Use of HDSF


AM 374 is an fatty acid amide hydrolase (FAAH) inhibitor. AM 374 inhibits amidase activity with an IC50 value of 13 nM. AM 374 can be used for the research of neurological disease[1][2].

 Names

Name hexadecane-1-sulfonyl fluoride
Synonym More Synonyms

 HDSF Biological Activity

Description AM 374 is an fatty acid amide hydrolase (FAAH) inhibitor. AM 374 inhibits amidase activity with an IC50 value of 13 nM. AM 374 can be used for the research of neurological disease[1][2].
Related Catalog
Target

IC50: 13 nM (amidase)[1]

In Vitro AM 374 (0-9 nM) 抑制 N18TG2 细胞中 anandamide 分解[1]。
In Vivo AM 374 (20 μg;心室内注射,1 次) 对 FR5 杠杆按压无影响,但与 anandamide (腹腔注射) 共同使用时减少杠杆按压[2]。 Animal Model: Adult male Sprague-Dawley rats with lever press training[2] Dosage: 20 μg Administration: Intraventricular (ICV) injection; 20 μg, once Result: Significantly reduced lever pressing when combined treatment with anandamide.
References

[1]. Deutsch DG, et al. Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor. Biochem Biophys Res Commun. 1997 Feb 3;231(1):217-21.  

[2]. Arizzi MN, et al. Behavioral effects of inhibition of cannabinoid metabolism: The amidase inhibitor AM374 enhances the suppression of lever pressing produced by exogenously administered anandamide. Life Sci. 2004 Jan 9;74(8):1001-11.  

 Chemical & Physical Properties

Density 0.966g/cm3
Boiling Point 388.3ºC at 760 mmHg
Molecular Formula C16H33FO2S
Molecular Weight 308.49500
Flash Point 188.6ºC
Exact Mass 308.21900
PSA 42.52000
LogP 6.84780
Index of Refraction 1.445
Storage condition -20°C

 Safety Information

HS Code 2904909090

 Synthetic Route

~96%

HDSF Structure

HDSF

CAS#:86855-26-7

Literature: Hyatt, John A.; White, Alan W. Synthesis, 1984 , # 3 p. 214 - 217

 Precursor & DownStream

Precursor  1

DownStream  1

 Customs

HS Code 2904909090
Summary HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Synonyms

Hexadecanesulfonyl fluoride
Hexadecylsulfonyl fluoride
hdsf
palmitylsulphonylfluoride
Palmitylsulfonyl Fluoride
AM 374
1-HEXADECYLSULFONYL FLUORIDE
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