SID7970631

Modify Date: 2024-01-31 15:49:16

SID7970631 Structure
SID7970631 structure
Common Name SID7970631
CAS Number 868224-75-3 Molecular Weight 452.45700
Density N/A Boiling Point N/A
Molecular Formula C24H24N2O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SID7970631


SID7970631, as an isoquinolinone analog, is a potent and selective submicromolar SF-1 inhibitor (IC50=255 nM). SID7970631 can be used for the research of cancer[1][2].

 Names

Name ethyl 2-[2-[2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl]-1-oxoisoquinolin-5-yl]oxypropanoate
Synonym More Synonyms

 SID7970631 Biological Activity

Description SID7970631, as an isoquinolinone analog, is a potent and selective submicromolar SF-1 inhibitor (IC50=255 nM). SID7970631 can be used for the research of cancer[1][2].
Related Catalog
Target

IC50: 255 nM (SF-1)[1][2]

In Vitro SID7970631 (CHO-K1 cells) displays a half-maximal cytotoxic effect. SID7970631 dose dependently inhibits luciferase expression in the SF-1 assay, giving the IC50 value of 255 nM. SID7970631 displays a cytotoxic effect not only on H295R/TR SF-1 cells, but also on SW-13 cells[1][2].
References

[1]. Madoux F, et al. Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol Pharmacol. 2008;73(6):1776-1784.

[2]. Doghman M, et al. Identification and characterization of steroidogenic factor-1 inverse agonists. Methods Enzymol. 2010;485:3-23.

 Chemical & Physical Properties

Molecular Formula C24H24N2O7
Molecular Weight 452.45700
Exact Mass 452.15800
PSA 105.09000
LogP 2.76790

 Synonyms

steroidogenic factor-1 inhibitor, sid7970631
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