SID7970631

Names

[ Name ]:
SID7970631

[Synonym ]:
steroidogenic factor-1 inhibitor, sid7970631

Biological Activity

[Description]:

SID7970631, as an isoquinolinone analog, is a potent and selective submicromolar SF-1 inhibitor (IC50=255 nM). SID7970631 can be used for the research of cancer[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 255 nM (SF-1)[1][2]

[In Vitro]

SID7970631 (CHO-K1 cells) displays a half-maximal cytotoxic effect. SID7970631 dose dependently inhibits luciferase expression in the SF-1 assay, giving the IC50 value of 255 nM. SID7970631 displays a cytotoxic effect not only on H295R/TR SF-1 cells, but also on SW-13 cells[1][2].

[References]

[1]. Madoux F, et al. Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol Pharmacol. 2008;73(6):1776-1784.

[2]. Doghman M, et al. Identification and characterization of steroidogenic factor-1 inverse agonists. Methods Enzymol. 2010;485:3-23.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₄N₂O₇

[ Molecular Weight ]:
452.45700

[ Exact Mass ]:
452.15800

[ PSA ]:
105.09000

[ LogP ]:
2.76790

Related Compounds

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