868224-75-3

868224-75-3 structure

Name: SID7970631
Chemical Name: ethyl 2-[2-[2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl]-1-oxoisoquinolin-5-yl]oxypropanoate
CAS Number: 868224-75-3
Molecular Formula: C₂₄H₂₄N₂O₇
Molecular Weight: 452.45700
Catalog: Research Areas Cancer
Create Date: 2016-01-14 20:43:50
Modify Date: 2024-01-31 15:49:16
SID7970631, as an isoquinolinone analog, is a potent and selective submicromolar SF-1 inhibitor (IC50=255 nM). SID7970631 can be used for the research of cancer[1][2].

Name	ethyl 2-[2-[2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl]-1-oxoisoquinolin-5-yl]oxypropanoate
Synonyms	steroidogenic factor-1 inhibitor, sid7970631

Description	SID7970631, as an isoquinolinone analog, is a potent and selective submicromolar SF-1 inhibitor (IC50=255 nM). SID7970631 can be used for the research of cancer[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 255 nM (SF-1)[1][2]
In Vitro	SID7970631 (CHO-K1 cells) displays a half-maximal cytotoxic effect. SID7970631 dose dependently inhibits luciferase expression in the SF-1 assay, giving the IC50 value of 255 nM. SID7970631 displays a cytotoxic effect not only on H295R/TR SF-1 cells, but also on SW-13 cells[1][2].
References	[1]. Madoux F, et al. Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol Pharmacol. 2008;73(6):1776-1784. [2]. Doghman M, et al. Identification and characterization of steroidogenic factor-1 inverse agonists. Methods Enzymol. 2010;485:3-23.