RO0335
Modify Date: 2025-09-04 11:40:14
RO0335 structure
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Common Name | RO0335 | ||
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| CAS Number | 867365-76-2 | Molecular Weight | 573.21900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H13BrCl2FN3O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RO0335RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor(NNRTI). RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates[1]. |
| Name | 2-[4-Bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]-N-(2-chlor o-4-sulfamoylphenyl)acetamide |
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| Description | RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor(NNRTI). RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C21H13BrCl2FN3O4S |
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| Molecular Weight | 573.21900 |
| Exact Mass | 570.91700 |
| PSA | 134.15000 |
| LogP | 7.81818 |
| InChIKey | SBUUICLVCQQMFP-UHFFFAOYSA-N |
| SMILES | N#Cc1cc(Cl)cc(Oc2c(Br)ccc(CC(=O)Nc3ccc(S(N)(=O)=O)cc3Cl)c2F)c1 |