RO0335

Names

[ Name ]:
RO0335

Biological Activity

[Description]:

RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor(NNRTI). RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Anti-infection >> Reverse Transcriptase

[References]

[1]. Javanbakht H, et al. In vitro resistance development for RO-0335, a novel diphenylether nonnucleoside reverse transcriptase inhibitor. Antiviral Res. 2010;86(2):212-219.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₃BrCl₂FN₃O₄S

[ Molecular Weight ]:
573.21900

[ Exact Mass ]:
570.91700

[ PSA ]:
134.15000

[ LogP ]:
7.81818

Related Compounds

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