Nudol
Modify Date: 2025-09-18 22:56:41
Nudol structure
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Common Name | Nudol | ||
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| CAS Number | 86630-46-8 | Molecular Weight | 270.28000 | |
| Density | N/A | Boiling Point | 512.4 °C at 760 mmHg | |
| Molecular Formula | C16H14O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NudolNudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits MMP-2M and MMP-9 activity (Ki: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma[1][2]. |
| Name | 3,4-dimethoxyphenanthrene-2,7-diol |
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| Synonym | More Synonyms |
| Description | Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits MMP-2M and MMP-9 activity (Ki: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma[1][2]. |
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| Related Catalog | |
| Target |
MMP-2:988.9 nM (Ki) MMP-9:1.76 μM (Ki) |
| In Vitro | Nudol (0-40 μM, 24-72 h) decreases cell viability in several cancer cell lines[1]. Nudol (0-20 μM, 24/48 h) suppresses the cell migration and causes cell cycle arrest at G2/M phase in U2OS cells[1]. Nudol (20 μM, 48 h) induces cell apoptosis through the caspase-dependent pathway in U2OS cells[1]. Nudol (compound 4) inhibits MMP-2 and MMP-9 activity with Ki values of 988.9 nM and 1.76 μM respectively[2]. Cell Viability Assay[1] Cell Line: U2OS, MG63, MDA-MB-231, MCF-7, and A549 cells Concentration: 0, 10, 20, 30, 40 μM Incubation Time: 24, 48, and 72 h Result: Decreased the cell viability of osteosarcoma cells in dose- and time-dependent manners. Cell Cycle Analysis[1] Cell Line: U2OS cells Concentration: 0, 5, 10, 20 μM Incubation Time: 24, 48, and 72 h Result: Triggered G2/M phase arrest by decreasing cell cycle-related proteins (CDK1, CDK2, CDK4, and CDK10). Western Blot Analysis[1] Cell Line: U2OS cells Concentration: 0, 5, 10, 20, 40 μM Incubation Time: 24, 48, and 72 h Result: Increased the protein level of cytochrome c. Down-regulated anti-apoptotic Bcl-2, accompanied by an increased level of pro-apoptotic Bax. |
| References |
| Boiling Point | 512.4 °C at 760 mmHg |
|---|---|
| Molecular Formula | C16H14O4 |
| Molecular Weight | 270.28000 |
| Exact Mass | 270.08900 |
| PSA | 58.92000 |
| LogP | 3.42140 |
| InChIKey | JZIYNZGPIKGKQC-UHFFFAOYSA-N |
| SMILES | COc1c(O)cc2ccc3cc(O)ccc3c2c1OC |
| Hazard Codes | Xi |
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| Precursor 0 | |
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| DownStream 2 | |
CAS#:86630-45-7
CAS#:97399-69-4| 2,7-Phenanthrenediol,3,4-dimethoxy |
| nudol |