Briciclib
Modify Date: 2024-01-04 12:17:43
Briciclib structure
|
Common Name | Briciclib | ||
|---|---|---|---|---|
| CAS Number | 865783-99-9 | Molecular Weight | 474.419 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 762.6±70.0 °C at 760 mmHg | |
| Molecular Formula | C19H23O10PS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 415.0±35.7 °C | |
Use of BriciclibBriciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers. |
| Name | 2-Methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methy l)phenyl dihydrogen phosphate |
|---|---|
| Synonym | More Synonyms |
| Description | Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers. |
|---|---|
| Related Catalog | |
| Target |
eIF4E[1] |
| In Vitro | Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 762.6±70.0 °C at 760 mmHg |
| Molecular Formula | C19H23O10PS |
| Molecular Weight | 474.419 |
| Flash Point | 415.0±35.7 °C |
| Exact Mass | 474.074951 |
| PSA | 156.01000 |
| LogP | 0.89 |
| Appearance of Characters | white solid |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.578 |
| Storage condition | -20℃ |
| 2-Methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methyl)phenyl dihydrogen phosphate |
| ON 014185 |
| Phenol, 2-methoxy-5-[[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]-, dihydrogen phosphate |
| Briciclib |
| Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate) |