CMPD101
Modify Date: 2025-08-20 17:55:32
CMPD101 structure
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Common Name | CMPD101 | ||
|---|---|---|---|---|
| CAS Number | 865608-11-3 | Molecular Weight | 466.458 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C24H21F3N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CMPD101CMPD101, is a novel membrane-permeable, small-molecule inhibitor of both GRK2 and GRK3 with IC50s of 18 nM and 5.4 nM. CMPD101 also inhibits ROCK-2 and PKCα (IC50s=1.4 μM and 8.1 μM, respectively)[1]. |
| Name | 3-({[4-Methyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]methyl}amino)-N-[2-(trifluoromethyl)benzyl]benzamide |
|---|---|
| Synonym | More Synonyms |
| Description | CMPD101, is a novel membrane-permeable, small-molecule inhibitor of both GRK2 and GRK3 with IC50s of 18 nM and 5.4 nM. CMPD101 also inhibits ROCK-2 and PKCα (IC50s=1.4 μM and 8.1 μM, respectively)[1]. |
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| Related Catalog | |
| Target |
GRK2:18 nM (IC50) GRK3:5.4 nM (IC50) PKCα:8.1 μM (IC50) ROCK2:1.4 μM (IC50) |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C24H21F3N6O |
| Molecular Weight | 466.458 |
| Exact Mass | 466.172882 |
| LogP | 3.30 |
| Index of Refraction | 1.622 |
| InChIKey | WFOVEDJTASPCIR-UHFFFAOYSA-N |
| SMILES | Cn1c(CNc2cccc(C(=O)NCc3ccccc3C(F)(F)F)c2)nnc1-c1ccncc1 |
| 3-({[4-Methyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]methyl}amino)-N-[2-(trifluoromethyl)benzyl]benzamide |
| Benzamide, 3-[[[4-methyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]methyl]amino]-N-[[2-(trifluoromethyl)phenyl]methyl]- |
| CMPD101 |