Fostemsavir Tris

Modify Date: 2025-09-11 12:31:00

Fostemsavir Tris Structure
Fostemsavir Tris structure
Common Name Fostemsavir Tris
CAS Number 864953-39-9 Molecular Weight 704.625
Density N/A Boiling Point N/A
Molecular Formula C29H37N8O11P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Fostemsavir Tris


Fostemsavir Tris (BMS-663068 (Tris)) is the phosphonooxymethyl prodrug of BMS-626529. Fostemsavir Tris (BMS-663068 (Tris)) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells.

 Names

Name BMS-663068 Tris
Synonym More Synonyms

 Fostemsavir Tris Biological Activity

Description Fostemsavir Tris (BMS-663068 (Tris)) is the phosphonooxymethyl prodrug of BMS-626529. Fostemsavir Tris (BMS-663068 (Tris)) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells.
Related Catalog
Target

HIV-1[1]

In Vivo Fostemsavir Tris has good antiviral activity in subjects infected with virus shown to be susceptible (IC50, <100 nM) to the agent[1].
References

[1]. Nowicka-Sans B, et al. In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068. Antimicrob Agents Chemother. 2012 Jul;56(7):3498-507.

 Chemical & Physical Properties

Molecular Formula C29H37N8O11P
Molecular Weight 704.625
Exact Mass 704.231934

 Synonyms

Fostemsavir tromethamine
1,2-Ethanedione, 1-(4-benzoyl-1-piperazinyl)-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
BMS-663068-03
{3-[(4-Benzoyl-1-piperazinyl)(oxo)acetyl]-4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl}methyl dihydrogen phosphate - 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
2X513P36U0
MFCD23098797
BMS-663068 (Tris)
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