Fostemsavir Tris

Names

[ Name ]:
Fostemsavir Tris

[Synonym ]:
Fostemsavir tromethamine
1,2-Ethanedione, 1-(4-benzoyl-1-piperazinyl)-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
BMS-663068-03
{3-[(4-Benzoyl-1-piperazinyl)(oxo)acetyl]-4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl}methyl dihydrogen phosphate - 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
2X513P36U0
MFCD23098797
BMS-663068 (Tris)

Biological Activity

[Description]:

Fostemsavir Tris (BMS-663068 (Tris)) is the phosphonooxymethyl prodrug of BMS-626529. Fostemsavir Tris (BMS-663068 (Tris)) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

[Target]

HIV-1[1]

[In Vivo]

Fostemsavir Tris has good antiviral activity in subjects infected with virus shown to be susceptible (IC50, <100 nM) to the agent[1].

[References]

[1]. Nowicka-Sans B, et al. In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068. Antimicrob Agents Chemother. 2012 Jul;56(7):3498-507.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₃₇N₈O₁₁P

[ Molecular Weight ]:
704.625

[ Exact Mass ]:
704.231934

Related Compounds

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