864953-39-9

864953-39-9 structure

Name: Fostemsavir Tris
Chemical Name: BMS-663068 Tris
CAS Number: 864953-39-9
Molecular Formula: C₂₉H₃₇N₈O₁₁P
Molecular Weight: 704.625
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2018-01-11 14:47:25
Modify Date: 2024-01-11 12:40:01
Fostemsavir Tris (BMS-663068 (Tris)) is the phosphonooxymethyl prodrug of BMS-626529. Fostemsavir Tris (BMS-663068 (Tris)) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells.

Name	BMS-663068 Tris
Synonyms	Fostemsavir tromethamine 1,2-Ethanedione, 1-(4-benzoyl-1-piperazinyl)-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) BMS-663068-03 {3-[(4-Benzoyl-1-piperazinyl)(oxo)acetyl]-4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl}methyl dihydrogen phosphate - 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) 2X513P36U0 MFCD23098797 BMS-663068 (Tris)

Description	Fostemsavir Tris (BMS-663068 (Tris)) is the phosphonooxymethyl prodrug of BMS-626529. Fostemsavir Tris (BMS-663068 (Tris)) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells.
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1[1]
In Vivo	Fostemsavir Tris has good antiviral activity in subjects infected with virus shown to be susceptible (IC50, <100 nM) to the agent[1].
References	[1]. Nowicka-Sans B, et al. In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068. Antimicrob Agents Chemother. 2012 Jul;56(7):3498-507.