TCA-1
Modify Date: 2025-09-05 14:46:30
TCA-1 structure
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Common Name | TCA-1 | ||
|---|---|---|---|---|
| CAS Number | 864941-32-2 | Molecular Weight | 375.422 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C16H13N3O4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TCA-1A small molecule with activity against drug-resistant and persistent tuberculosis; shows bactericidal activity against nonreplicating Mtb in vitro and is efficacious in acute and chronic Mtb infection mouse models; down-regulates genes known to be involved in Mtb persistence; inhibits DprE1 and MoeW, enzymes involved in cell wall and molybdenum cofactor biosynthesis. |
| Name | Ethyl ({2-[(1,3-benzothiazol-2-ylcarbonyl)amino]-3-thienyl}carbonyl)carbamate |
|---|---|
| Synonym | More Synonyms |
| Description | A small molecule with activity against drug-resistant and persistent tuberculosis; shows bactericidal activity against nonreplicating Mtb in vitro and is efficacious in acute and chronic Mtb infection mouse models; down-regulates genes known to be involved in Mtb persistence; inhibits DprE1 and MoeW, enzymes involved in cell wall and molybdenum cofactor biosynthesis. |
|---|---|
| References | References 1. Wang F, et al. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2510-7. View Related Products by Target Bacterial |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C16H13N3O4S2 |
| Molecular Weight | 375.422 |
| Exact Mass | 375.034760 |
| LogP | 4.47 |
| Index of Refraction | 1.709 |
| InChIKey | ISNBJLXHBBZKSL-UHFFFAOYSA-N |
| SMILES | CCOC(=O)NC(=O)c1ccsc1NC(=O)c1nc2ccccc2s1 |
| Carbamic acid, N-[[2-[(2-benzothiazolylcarbonyl)amino]-3-thienyl]carbonyl]-, ethyl ester |
| Ethyl ({2-[(1,3-benzothiazol-2-ylcarbonyl)amino]-3-thienyl}carbonyl)carbamate |
| MFCD04430653 |
| Ethyl ({2-[(1,3-Benzothiazol-2-Ylcarbonyl)amino]thiophen-3-Yl}carbonyl)carbamate |