864941-32-2
864941-32-2 structure
- Name: TCA-1
- Chemical Name: Ethyl ({2-[(1,3-benzothiazol-2-ylcarbonyl)amino]-3-thienyl}carbonyl)carbamate
- CAS Number: 864941-32-2
- Molecular Formula: C16H13N3O4S2
- Molecular Weight: 375.422
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2020-01-11 17:36:06
- Modify Date: 2024-01-05 07:03:04
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A small molecule with activity against drug-resistant and persistent tuberculosis; shows bactericidal activity against nonreplicating Mtb in vitro and is efficacious in acute and chronic Mtb infection mouse models; down-regulates genes known to be involved in Mtb persistence; inhibits DprE1 and MoeW, enzymes involved in cell wall and molybdenum cofactor biosynthesis.
| Name | Ethyl ({2-[(1,3-benzothiazol-2-ylcarbonyl)amino]-3-thienyl}carbonyl)carbamate |
|---|---|
| Synonyms |
Carbamic acid, N-[[2-[(2-benzothiazolylcarbonyl)amino]-3-thienyl]carbonyl]-, ethyl ester
Ethyl ({2-[(1,3-benzothiazol-2-ylcarbonyl)amino]-3-thienyl}carbonyl)carbamate MFCD04430653 Ethyl ({2-[(1,3-Benzothiazol-2-Ylcarbonyl)amino]thiophen-3-Yl}carbonyl)carbamate |
| Description | A small molecule with activity against drug-resistant and persistent tuberculosis; shows bactericidal activity against nonreplicating Mtb in vitro and is efficacious in acute and chronic Mtb infection mouse models; down-regulates genes known to be involved in Mtb persistence; inhibits DprE1 and MoeW, enzymes involved in cell wall and molybdenum cofactor biosynthesis. |
|---|---|
| References | References 1. Wang F, et al. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2510-7. View Related Products by Target Bacterial |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C16H13N3O4S2 |
| Molecular Weight | 375.422 |
| Exact Mass | 375.034760 |
| LogP | 4.47 |
| Index of Refraction | 1.709 |