Casein Kinase II Inhibitor IV

Modify Date: 2024-01-13 17:50:04

Casein Kinase II Inhibitor IV structure	Common Name	Casein Kinase II Inhibitor IV
	CAS Number	863598-09-8	Molecular Weight	429.47100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₃N₅O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Casein Kinase II Inhibitor IV

Casein Kinase II Inhibitor IV is a small-molecule inducer of epidermal keratinocyte differentiation.

Name	3-[3-[2-(3,4,5-trimethoxyanilino)pyrrolo[2,3-d]pyrimidin-7-yl]phenyl]propanenitrile
Synonym	More Synonyms

Description	Casein Kinase II Inhibitor IV is a small-molecule inducer of epidermal keratinocyte differentiation.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase Research Areas >> Others
Target	Target: Casein Kinase[1]
In Vitro	Treatment of human epidermal keratinocytes (NHEKs) with Casein Kinase II Inhibitor IV leads to an increase in the early differentiation markers keratins 1 and 10 at 48 h. Increased levels of IVL and TGM are observed in cells treated with Casein Kinase II Inhibitor IV at 72 h and persisted at 96 h. In addition, treated with Casein Kinase II Inhibitor IV expressesloricrin, a terminal differentiation marker, at later time points. Similar results are observed by messenger RNA (mRNA) expression analysis of NHEKs treated with Casein Kinase II Inhibitor IV. At early time points (12 and 24 h), treatment with Casein Kinase II Inhibitor IV leads to the upregulation of keratinocyte early differentiation marker genes, including keratin 1 (5.4-fold) and keratin 10 (5.4-fold). Terminal differentiation marker genes, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), are upregulated at late time points (36 and 48 h). These results are again consistent with the ability of Casein Kinase II Inhibitor IV to induce differentiation of epidermal progenitor cells into terminally differentiated keratinocytes[1].
Kinase Assay	For reporter gene assays with transiently transfected cells, the cells are typically transfected in 150 mm-diam dishes when 30-40% confluent. A reporter plasmid, pGL3/3.7 kbp-IVLLuc plasmid, is transfected into the NHEKs. After 24 h, the transfected cells are plated into 96-well assay plates and treated with compound (Casein Kinase II Inhibitor IV) to a final concentration of 5 μM. After incubation for 2 d, reporter gene activity is measured using the Bright-Glo luciferase assay system[1].
References	[1]. Hong J, et al. Identification and characterization of small-molecule inducers of epidermal keratinocyte differentiation. ACS Chem Biol. 2007 Mar 20;2(3):171-5.

Molecular Formula	C₂₄H₂₃N₅O₃
Molecular Weight	429.47100
Exact Mass	429.18000
PSA	94.22000
LogP	4.71908
Storage condition	2-8℃

3,4,5-Trimethoxyaniline structure

3,4,5-Trimethox...

CAS#:24313-88-0

~%

Casein Kinase II Inhibitor IV Structure

Casein Kinase I...

CAS#:863598-09-8

Literature: Choi, Ha-Soon; Wang, Zhicheng; Richmond, Wendy; He, Xiaohui; Yang, Kunyong; Jiang, Tao; Karanewsky, Donald; Gu, Xiang-ju; Zhou, Vicki; Liu, Yi; Che, Jianwei; Lee, Christian C.; Caldwell, Jeremy; Kanazawa, Takanori; Umemura, Ichiro; Matsuura, Naoko; Ohmori, Osamu; Honda, Toshiyuki; Gray, Nathanael; He, Yun Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 10 p. 2689 - 2692

Keratinocyte Differentiation Inducer

3-{3-[2-(3,4,5-trimethoxy-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-propionitrile

HMS3229D03

Casein Kinase II Inhibitor IV

DC Chemicals Limited
China
Product Name: CK2-IN-1
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

Casein Kinase II Inhibitor IV suppliers

Price: $385/10mM*1mLinDMSO

Reference only. check more Casein Kinase II Inhibitor IV price